Animal ID:
N/A
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Host:
Rabbit
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Reactivity:
Human
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Storage:
Maintain refrigerated at 2-8oC for up to 6 months. For long term storage store ar -20oC. Avoid repeated freeze-thaw cycles.
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Immunogen:
KLH conjugated synthethic peptide comprised of N-terminal domain of the human Caveolin-1.
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Accession number:
NM_001753
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Description:
Caveolin 1 is the main component of the caveolae plasma membranes found in most cell types. Caveolin 1 functions as a membrane adaptor to link integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. CAV1 may also be a tumor suppressor gene and a negative regulator of the Ras-p42/44 MAP kinase cascade.
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Alternative Name(s):
CAV; cav1; caveolin-1; VIP21
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References:
- Engelman JA, Zhang XL, and Lisanti MP: Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1). Methylation of a CpG island in the 5' promoter region of the caveolin-1 gene in human breast cancer cell lines. FEBS Lett Apr. 448: 221-30 (1999).
- Fra AM, Mastroianni N, Mancini M, Pasqualetto E, and Sitia R: Human caveolin-1 and caveolin-2 are closely linked genes colocalized with WI-5336 in a region of 7q31 frequently deleted in tumors. Genomics Mar. 56: 355-6 (1999).
- Hurlstone AF, Reid G, Reeves JR, Fraser J, Strathdee G, Rahilly M, Parkinson EK, and Black DM: Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines. Oncogene Mar. 18: 1881-90 (1999).
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For Research Use Only. Not for Diagnostic or Therapeutic Use.
Purchase does not include or carry any right to resell or transfer this product either as a stand-alone product or as a component of another product. Any use of this product other than the permitted use without the express written authorization of Orbigen, Inc. is strictly prohibited
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