Animal ID:
RB0199-0200
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Host:
Rabbit
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Reactivity:
human
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Buffers:
Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
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Storage:
Maintain refrigerated at 2-8ºC for up to 6 months. For long term storage store at -20ºC. Avoid repeated freeze-thaw cycles.
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Application:
Tested by peptide-specific ELISA (1:1,000).
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Immunogen:
KLH conjugated synthetic peptide comprised of amino acids 519 - 535 [SPFDKEAEGQFYNYFPN] of the human T-box 21 (TBX21) protein.
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Accession number:
NM_013351
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Description:
T-box transcription factors contain a novel type of DNA-binding domain, the T-box domain, which are encoded by an ancient gene family. Four T-box genes, omb, Trg, org-1, and H15, have been identified in Drosophila, whereas in mammals the T-box gene family has expanded, and 12 human T-box genes have been isolated. Most T-box genes have discrete spatial and temporal patterns of expression during embryogenesis. T-box 21 (TBX21) is the human ortholog of mouse Tbx21/Tbet gene and studies in mice have shown that Tbx21 is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of human TBX21 also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for TBX21 in initiating Th1 lineage development from naive Th precursor cells.
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Alternative Name(s):
T-box 21, T-PET, T-bet, TBLYM, T-box expressed in T cells, T-cell-specific T-box transcription factor
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References:
- Faedo A, Ficara F, Ghiani M, Aiuti A, Rubenstein JL, Bulfone A.: Developmental expression of the T-box transcription factor T-bet/Tbx21 during mouse embryogenesis. Mech. Dev. 116(1-2): 157-160 (2002).
- Zhang WX, Yang SY: Cloning and characterization of a new member of the T-box gene family. Genomics 70(1): 41-48 (2000).
- Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH: A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100(6): 655-669 (2000).
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For Research Use Only. Not for Diagnostic or Therapeutic Use.
Purchase does not include or carry any right to resell or transfer this product either as a stand-alone product or as a component of another product. Any use of this product other than the permitted use without the express written authorization of Orbigen, Inc. is strictly prohibited
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