Animal ID:
RB0675-0676
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Host:
Rabbit
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Reactivity:
Human
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Buffers:
Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
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Storage:
Maintain refrigerated at 2-8ºC for up to 6 months. For long term storage store at -20ºC. Avoid repeated freeze-thaw cycles.
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Application:
Tested by peptide-specific ELISA (1:1,000).
WB (1:100 ~1:500), IHC (1:50 ~1:100)
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Immunogen:
KLH conjugated synthetic peptide comprised of amino acids 1 - 10 [MADFEELRNM] of the human Msx-interacting-zinc finger (MIZ1) [N-terminus] protein.
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Accession number:
NM_004671
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Description:
Msx-interacting-zinc finger (MIZ1) is a member of the mammalian PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family which contains a putative zinc-binding motif and a highly acidic region. MIZ1 is strongly similar to murine MIz1 and may stimulate transcription. Expression of Miz1 increases during hematopoietic differentiation and Miz1 activates the p21 promoter under conditions of low Myc levels.
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Alternative Name(s):
PIASX-BETA, Protein inhibitor of activated STAT X, PIASX-ALPHA, SIZ2, PIASX-BETA, PIASX-ALPHA, PIASx1
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References:
- Tan JA, Hall SH, Hamil KG, Grossman G, Petrusz P, French FS: Protein inhibitors of activated STAT resemble scaffold attachment factors and function as interacting nuclear receptor coregulators. J. Biol. Chem. 277: 16993-17001 (2002).
- Takahashi K, Taira T, Niki T, Seino C, Iguchi-Ariga SM, Ariga H: DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor. J. Biol. Chem 276: 37556-37563 (2001).
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For Research Use Only. Not for Diagnostic or Therapeutic Use.
Purchase does not include or carry any right to resell or transfer this product either as a stand-alone product or as a component of another product. Any use of this product other than the permitted use without the express written authorization of Orbigen, Inc. is strictly prohibited
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