Animal ID:
RB2019/2020
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Host:
Rabbit
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Reactivity:
Human, Mouse
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Buffers:
Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
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Storage:
Maintain refrigerated at 2-8ºC for up to 6 months. For long term storage store at -20ºC. Avoid repeated freeze-thaw cycles.
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Application:
Tested by peptide-specific ELISA (1:1,000).
WB (1:100 ~1:500), IHC (1:50 ~1:100)
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Immunogen:
KLH conjugated synthetic peptide comprised of amino acids 659 - 674 [LDTHDVFQYREKAYFC] of the human matrix metalloproteinase 9 (MMP9) protein.
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Accession number:
NM_004994
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Description:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. Matrix metalloproteinase 9 (MMP9) degrades type IV and V collagens very actively. Studies in rhesus monkeys have shown that MMP9 is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow.
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Alternative Name(s):
matrix metalloproteinase 9, GELB, CLG4B, gelatinase B type V collagenase, macrophage gelatinase, 92kD type IV collagenase, matrix metalloproteinase 9, MMP9
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References:
- Wang TN, Albo D, Tuszynski GP: Fibroblasts promote breast cancer cell invasion by upregulating tumor matrix metalloproteinase-9 production. Surgery 132(2): 220-225 (2002).
- Cha H, Kopetzki E, Huber R, Lanzendorfer M, Brandstetter H: Structural basis of the adaptive molecular recognition by MMP9. J. Mol. Biol. 320(5): 1065-1079 (2002).
- Faber-Elmann A, Sthoeger Z, Tcherniack A, Dayan M, Mozes E: Activity of matrix metalloproteinase-9 is elevated in sera of patients with systemic lupus erythematosus. Clin. Exp. Immunol. 127(2): 393-398 (2002).
- Yeo SJ, Yun YJ, Lyu MA, Woo SY, Woo ER, Kim SJ, Lee HJ, Park HK, Kook YH: Respiratory syncytial virus infection induces matrix metalloproteinase-9 expression in epithelial cells. Arch. Virol. 147(2): 229-242 (2002).
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For Research Use Only. Not for Diagnostic or Therapeutic Use.
Purchase does not include or carry any right to resell or transfer this product either as a stand-alone product or as a component of another product. Any use of this product other than the permitted use without the express written authorization of Orbigen, Inc. is strictly prohibited
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