Animal ID:
RB0655-0656
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Host:
Rabbit
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Reactivity:
human
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Buffers:
Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
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Storage:
Maintain refrigerated at 2-8ºC for up to 6 months. For long term storage store at -20ºC. Avoid repeated freeze-thaw cycles.
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Application:
Tested by peptide-specific ELISA (1:1,000).
WB (1:100 ~1:500), IHC (1:50 ~1:100)
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Immunogen:
N/A
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Accession number:
NM_015670
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Description:
Covalent attachment of one protein to another is one of the more prominent posttranslational modifications in respects to size and ubiquity ¿ to which eukaryotic proteins are subject. Ubiquitin is the most familiar of the protein modifiers and its activation and transfer to target proteins has been studied for over two decades. Recently a new group of ubiquitin-like (Ubl) proteins have come to light. One of the most intriguing of them is SUMO (small ubiquitin-like modifier) also known as Sentrin. Sentrin-1 is a protein of 101 residues that is distantly related to ubiquitin and another ubiquitin-like protein, NEDD8. Sentrin/SUMO proteins have been described in many vertebrates. They have been shown to bind and regulate mammalian SP-RINGs (such as Mdm2, PIAS and PML), RanGAP1, RanBP2, p53, p73, HIPK2, TEL, c-Jun, Fas, Daxx, TNFRI, Topo-I, Topo-II, WRN, Sp100, IkB-alpha, Androgen receptor, GLUT1/4, Drosophila Ttk69, Dorsal, CaMK, yeast septins, and viral CMV-IE1/2, EBV-BZLF1 and HPV/BPV-E1 expression. Thus, SUMO may be involved in stabilizing target proteins and/or influence their subcellular localization. Sentrin/SUMO-specific protease 3 (SENP3) is involved in destabilizing and degradation of specific protein complexes. Its precise biological role is currently unknown.
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Alternative Name(s):
SSP3, SMT3IP1, DKFZP586K0919, SENP3, Sentrin-specific protease 3, SUMO-1 specific protease 3
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References:
- Zhang H, Saitoh H, Matunis MJ: Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex. Mol. Cell. Biol. 22(18): 6498-6508 (2002).
- Yeh ET, Gong L, Kamitani T: Ubiquitin-like proteins: new wines in new bottles. Gene 248 (1-2): 1-14 (2000).
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For Research Use Only. Not for Diagnostic or Therapeutic Use.
Purchase does not include or carry any right to resell or transfer this product either as a stand-alone product or as a component of another product. Any use of this product other than the permitted use without the express written authorization of Orbigen, Inc. is strictly prohibited
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