Animal ID:
RB0469-0470
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Host:
Rabbit
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Reactivity:
human
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Buffers:
Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
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Storage:
Maintain refrigerated at 2-8ºC for up to 6 months. For long term storage store at -20ºC. Avoid repeated freeze-thaw cycles.
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Application:
Tested by peptide-specific ELISA (1:1,000).
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Immunogen:
KLH conjugated synthetic peptide comprised of amino acids 52 - 67 [NTLTKPTSDPWMPSGS] of the human protein tyrosine phosphatase receptor-type M (PTPRM) protein.
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Accession number:
NM_002845
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Description:
Protein tyrosine phosphatase receptor type M (PTPRM) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPRM possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. PTPRM mediates cell-cell aggregation through the interaction with another molecule of PTPRM on an adjacent cell. Additionally, PTPRM can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion.
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Alternative Name(s):
RPTPM, RPTPU, PTPRL1, hR-PTPu, R-PTP-MU
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References:
- Blanchetot C, Tertoolen LG, Overvoorde J, den Hertog J: Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases. J. Biol. Chem. 277(49): 47263-47269 (2002).
- Mourton T, Hellberg CB, Burden-Gulley SM, Hinman J, Rhee A, Brady-Kalnay SM: The PTPmu protein-tyrosine phosphatase binds and recruits the scaffolding protein RACK1 to cell-cell contacts. J. Biol. Chem. 276(18): 14896-14901 (2001).
- Feiken E, van Etten I, Gebbink MF, Moolenaar WH, Zondag GC: Intramolecular interactions between the juxtamembrane domain and phosphatase domains of receptor protein-tyrosine phosphatase RPTPmu. Regulation of catalytic activity. J. Biol. Chem. 275(20): 15350-15356 (2000).
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For Research Use Only. Not for Diagnostic or Therapeutic Use.
Purchase does not include or carry any right to resell or transfer this product either as a stand-alone product or as a component of another product. Any use of this product other than the permitted use without the express written authorization of Orbigen, Inc. is strictly prohibited
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