Animal ID:
RB0541-0542
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Host:
Rabbit
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Reactivity:
mouse
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Buffers:
Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
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Storage:
Maintain refrigerated at 2-8ºC for up to 6 months. For long term storage store at -20ºC. Avoid repeated freeze-thaw cycles.
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Application:
Tested by peptide-specific ELISA (1:1,000).
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Immunogen:
KLH conjugated synthetic peptide comprised of amino acids 128 - 144 [SLSRSYFKDRAHIQSLF] of the mouse multiple endocrine neoplasia 1 (Men1) protein.
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Accession number:
NM_008583
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Description:
Multiple endocrine neoplasia I (Men1), or also called menin, is a putative tumor suppressor protein. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known.
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Alternative Name(s):
MEAI, SCG2, menin
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References:
- Forsberg L, Zablewska B, Piehl F, Weber G, Lagercrantz S, Gaudray P, Hoog C, Larsson C: Differential expression of multiple alternative spliceforms of the Men1 tumor suppressor gene in mouse. Int. J. Mol. Med. 8(6): 681-689 (2001).
- Maruyama K, Tsukada T, Hosono T, Ohkura N, Kishi M, Honda M, Nara-Ashizawa N, Nagasaki K, Yamaguchi K: Structure and distribution of rat menin mRNA. Mol. Cell. Endocrinol. 156(1-2): 25-33 (1999).
- Karges W, Maier S, Wissmann A, Dralle H, Dosch HM, Boehm BO: Primary structure, gene expression and chromosomal mapping of rodent homologs of the MEN1 tumor suppressor gene. Biochim. Biophys. Acta. 1446(3): 286-294 (1999).
- Guru SC, Crabtree JS, Brown KD, Dunn KJ, Manickam P, Prasad NB, Wangsa D, Burns AL, Spiegel AM, Marx SJ, Pavan WJ, Collins FS, Chandrasekharappa SC: Isolation, genomic organization, and expression analysis of Men1, the murine homolog of the MEN1 gene. Mamm. Genome. 10(6): 592-596 (1999).
- Stewart C, Parente F, Piehl F, Farnebo F, Quincey D, Silins G, Bergman L, Carle GF, Lemmens I, Grimmond S, Xian CZ, Khodei S, Teh BT, Lagercrantz J, Siggers P, Calender A, Van de Vem V, Kas K, Weber G, Hayward N, Gaudray P, Larsson C: Characterization of the mouse Men1 gene and its expression during development. Oncogene 17(19): 2485-2493 (1998).
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For Research Use Only. Not for Diagnostic or Therapeutic Use.
Purchase does not include or carry any right to resell or transfer this product either as a stand-alone product or as a component of another product. Any use of this product other than the permitted use without the express written authorization of Orbigen, Inc. is strictly prohibited
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