Animal ID:
RB2261/2262
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Host:
Rabbit
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Reactivity:
Human
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Buffers:
Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
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Storage:
Maintain refrigerated at 2-8ºC for up to 6 months. For long term storage store at -20ºC. Avoid repeated freeze-thaw cycles.
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Application:
Tested by peptide-specific ELISA (1:1,000).
WB (1:100 ~1:500), IHC (1:50 ~1:100)
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Immunogen:
KLH conjugated synthetic peptide comprised of amino acids 288 - 302 [ARAEASMRARASARA] of the human melanoma antigen family F 1 (MAGEF1) protein.
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Accession number:
NM_022149
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Description:
The human MAGE genes are expressed in a wide variety of tumors but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. Aberrant MAGE expression lead to tumor-specific antigens recognized on a human melanoma by autologous cytolytic T lymphocytes. The human MAGE genes are located on the X chromosome, in four clusters denoted MAGE-A, B, C, and D mapping at q28, p21.3, q26, and p11.2, respectively. Human MAGE-F1 is an intronless gene that is ubiquitously expressed in normal tissues and in tumor cells. Human MAGE-F1 includes a microsatellite repeat in the coding region. The cellular function of MAGE proteins in general is still unknown.
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Alternative Name(s):
Member F1 of the melanoma antigen family, melanoma-associated antigen F1, MAGEF1
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References:
- Stone B, Schummer M, Paley PJ, Crawford M, Ford M, Urban N, Nelson BH: MAGE-F1, a novel ubiquitously expressed member of the MAGE superfamily. Gene 267(2): 173-182 (2001).
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For Research Use Only. Not for Diagnostic or Therapeutic Use.
Purchase does not include or carry any right to resell or transfer this product either as a stand-alone product or as a component of another product. Any use of this product other than the permitted use without the express written authorization of Orbigen, Inc. is strictly prohibited
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