Animal ID:
RB2133/2134
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Host:
Rabbit
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Reactivity:
Human
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Buffers:
Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
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Storage:
Maintain refrigerated at 2-8ºC for up to 6 months. For long term storage store at -20ºC. Avoid repeated freeze-thaw cycles.
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Application:
Tested by peptide-specific ELISA (1:1,000).
IHC (1:50 ~1:100)
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Immunogen:
KLH conjugated synthetic peptide comprised of amino acids 864 - 880 [LSPFSEESSSPVDEYTS] of the human melanoma antigen family C 1 (MAGEC1) protein.
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Accession number:
NM_005462
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Description:
The human MAGE genes are expressed in a wide variety of tumors but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. Genes of the MAGE family direct the expression of tumor-specific antigens recognized on a human melanoma by autologous cytolytic T lymphocytes. The MAGE genes are located on the X chromosome, in four clusters denoted MAGE-A, B, C, and D mapping at q28, p21.3, q26, and p11.2, respectively. MAGE-C1 contains a large number of unique short repetitive sequences in front of the MAGE-homologous sequence, thus is about 800 residues longer than the other MAGE proteins. MAGE-C1 is expressed in a significant proportion of tumors of various histological types, whereas it is silent in normal tissues, except testis. The function of this gene is unknown.
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Alternative Name(s):
Member C1 of the melanoma antigen family, melanoma-associated antigen C1, CT7, MAGEC1
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References:
- Jungbluth AA, Chen YT, Busam KJ, Coplan K, Kolb D, Iversen K, Williamson B, Van Landeghem FK, Stockert E, Old LJ: CT7 (MAGE-C1) antigen expression in normal and neoplastic tissues. Int. J. Cancer. 99(6): 839-845 (2002).
- Lim SH, Bumm K, Chiriva-Intemati M, Xue Y, Wang Z: MAGE-C1 (CT7) gene expression in multiple myeloma: relationship to sperm protein 17. Eur. J. Haematol. 67(5-6): 332-334 (2001).
- Chen YT, Gure AO, Tsang S, Stockert E, Jager E, Knuth A, Old LJ: Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library. Proc. Natl. Acad. Sci. U S A. 95(12): 6919-6923 (1998).
- Lucas S, De Smet C, Arden KC, Viars CS, Lethe B, Lurquin C, Boon T: Identification of a new MAGE gene with tumor-specific expression by representational difference analysis. Cancer Res. 58(4): 743-752 (1998).
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For Research Use Only. Not for Diagnostic or Therapeutic Use.
Purchase does not include or carry any right to resell or transfer this product either as a stand-alone product or as a component of another product. Any use of this product other than the permitted use without the express written authorization of Orbigen, Inc. is strictly prohibited
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