Animal ID:
RB2069/2070
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Host:
Rabbit
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Reactivity:
Human
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Buffers:
Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
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Storage:
Maintain refrigerated at 2-8ºC for up to 6 months. For long term storage store at -20ºC. Avoid repeated freeze-thaw cycles.
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Application:
Tested by peptide-specific ELISA (1:1,000).
WB (1:100 ~1:500)
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Immunogen:
KLH conjugated synthetic peptide comprised of amino acids 166 - 180 [DPPGAPHTEEEGAED] of the human neuroblastoma suppression of tumorigenicity 1 (NBL1) protein.
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Accession number:
NM_005380
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Description:
The neuroblastoma suppression of tumorigenicity protein 1 (NBL1), also called DAN, acts as an inhibitor of cell cycle progression and is closely involved in retinoic acid-induced neuroblastoma differentiation. NBL1 as well as p73, a p53 family member, is up-regulated during osteoblast differentiation and expression of NBL1 increases in response to cisplatin-induced cell death of neuroblastoma SH-SY5Y cells. A functional association between NBL1 and p73 may exist during osteoblast differentiation as well as cisplatin-induced cell death.
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Alternative Name(s):
neuroblastoma suppression of tumorigenicity 1, NB, DAN, N03, NO3, D1S1733E, NBL1
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References:
- Shinbo J, Ozaki T, Nakagawa T, Watanabe K, Nakamura Y, Yamazaki M, Moriya H, Nakagawara A, Sakiyama S:p73-dependent expression of DAN during cisplatin-induced cell death and osteoblast differentiation. Biochem. Biophys. Res. Commun. 295(2): 501-507 (2002).
- Enomoto H, Ozaki T, Takahashi E, Nomura N, Tabata S, Takahashi H, Ohnuma N, Tanabe M, Iwai J, Yoshida H, et al.:Identification of human DAN gene, mapping to the putative neuroblastoma tumor suppressor locus. Oncogene 9(10): 2785-2791 (1994).
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For Research Use Only. Not for Diagnostic or Therapeutic Use.
Purchase does not include or carry any right to resell or transfer this product either as a stand-alone product or as a component of another product. Any use of this product other than the permitted use without the express written authorization of Orbigen, Inc. is strictly prohibited
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