Animal ID:
RB0575/RB0576
|
Host:
Rabbit
|
Reactivity:
Human, Mouse, Rat
|
Buffers:
Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
|
Storage:
Maintain refrigerated at 2-8ºC for up to 6 months. For long term storage store at -20ºC. Avoid repeated freeze-thaw cycles.
|
Application:
Tested by peptide-specific ELISA (1:1,000).
|
|
Immunogen:
KLH conjugated synthetic peptide comprised of amino acids 95 - 108 [MPLGHIMRLDLEKI] of the human egl nine homolog 3 (EGLN3) protein.
|
Accession number:
NM_022073
|
Description:
Hypoxia-inducible factor (HIF), a transcriptional complex conserved from Caenorhabditis elegans to vertebrates, plays a pivotal role in cellular adaptation to low oxygen availability. In normoxia, the HIF-alpha subunits are targeted for destruction by prolyl hydroxylation, a specific modification that provides recognition for the E3 ubiquitin ligase complex containing the von Hippel-Lindau tumour suppressor protein (pVHL). Three HIF prolyl-hydroxylases (PHD1, 2 and 3) were identified recently in mammals and shown to hydroxylate HIF-alpha subunits.
|
Alternative Name(s):
PHD3, HIFPH3, FLJ21620
|
References:
- Taylor MS: Characterization and comparative analysis of the EGLN gene family. Gene 275(1): 125-132 (2001).
|
For Research Use Only. Not for Diagnostic or Therapeutic Use.
Purchase does not include or carry any right to resell or transfer this product either as a stand-alone product or as a component of another product. Any use of this product other than the permitted use without the express written authorization of Orbigen, Inc. is strictly prohibited
|
|
