Animal ID:
RB4551-4552
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Host:
Rabbit
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Reactivity:
human
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Buffers:
Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
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Storage:
Maintain refrigerated at 2-8ºC for up to 6 months. For long term storage store at -20ºC. Avoid repeated freeze-thaw cycles.
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Application:
Tested by peptide-specific ELISA (1:1,000).
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Immunogen:
KLH conjugated synthetic peptide comprised of amino acids 1447 - 1453 [KELHGFL] of the human intersectin 2 (ITSN2) protein.
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Accession number:
NM_006277
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Description:
Intersectin 2 (ITSN2) contains several SH3 domains and is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 seems to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis.
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Alternative Name(s):
SWA, SWAP, SH3D1B, SH3P18, KIAA1256, SH3 domain protein 1B, SH3P18-like WASP associated protein
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References:
- McGavin MK, Badour K, Hardy LA, Kubiseski TJ, Zhang J, Siminovitch KA: The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis. J. Exp. Med. 194(12): 1777-1787 (2001).
- Pucharcos C, Casas C, Nadal M, Estivill X, de la Luna S: The human intersectin genes and their spliced variants are differentially expressed. Biochim. Biophys. Acta 1521(1-3): 1-11 (2001).
- Pucharcos C, Estivill X, de la Luna S: Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis. FEBS Lett. 478(1-2): 43-51 (2000).
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For Research Use Only. Not for Diagnostic or Therapeutic Use.
Purchase does not include or carry any right to resell or transfer this product either as a stand-alone product or as a component of another product. Any use of this product other than the permitted use without the express written authorization of Orbigen, Inc. is strictly prohibited
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