Animal ID:
RC40104
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Host:
Rabbit
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Reactivity:
human
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Buffers:
Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
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Storage:
Maintain refrigerated at 2-8ºC for up to 6 months. For long term storage store at -20ºC. Avoid repeated freeze-thaw cycles.
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Application:
Tested by peptide-specific ELISA (1:1,000), WB (1:1,000).
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Immunogen:
KLH conjugated synthetic peptide comprised of amino acids 677 - 692 [GESIAVKKRKCSLLDT] of the human "DNA cross-link repair 1C (DCLRE1C, PSO2, artemis)" protein.
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Accession number:
NM_022487
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Description:
DNA cross-link repair 1C (DCLRE1C, PSO2, artemis) is involved in V(D)J recombination and DNA repair. DCLRE1C has a role in T and B lymphocyte immunodeficiency and in predisposition to lymphoma through the NHEJ pathway of DNA repair. Artemis mutations cause human T-B-severe combined immunodeficiency associated with increased cellular radiosensitivity (RS-SCID). DNA-PKcs regulates DCLRE1C by both phosphorylation and complex formation to permit enzymatic activities that are critical for the hairpin-opening step of V(D)J recombination and for the 5' and 3' overhang processing in nonhomologous DNA end joining.
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Alternative Name(s):
SCIDA, SNM1C, ARTEMIS, RS-SCID, DCLREC1C, FLJ11360, A-SCID, artemis protein
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References:
- Moshous D, Callebaut I, de Chasseval R, Corneo B, Cavazzana-Calvo M, Le Deist F, Tezcan I, Sanal O, Bertrand Y, Philippe N, Fischer A, de Villartay JP: Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency. Cell 105(2): 177-186 (2001).
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For Research Use Only. Not for Diagnostic or Therapeutic Use.
Purchase does not include or carry any right to resell or transfer this product either as a stand-alone product or as a component of another product. Any use of this product other than the permitted use without the express written authorization of Orbigen, Inc. is strictly prohibited
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