Animal ID:
RB0759-0760
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Host:
Rabbit
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Reactivity:
human
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Buffers:
Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
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Storage:
Maintain refrigerated at 2-8ºC for up to 6 months. For long term storage store at -20ºC. Avoid repeated freeze-thaw cycles.
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Application:
Tested by peptide-specific ELISA (1:1,000).
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Immunogen:
KLH conjugated synthetic peptide comprised of amino acids 1 - 17 [MSAEVRLRRLQQLVLDP] of the human dystrophia myotonica-protein kinase (DMPK) protein.
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Accession number:
NM_004409
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Description:
Dystrophia myotonica-protein kinase (DMPK) is the protein product of the human DM-1 locus on chromosome 19q13.1 and has been implicated in the cardiac and behavioral dysfunctions of the disorder. DMPK contains four distinct regions: a leucine-rich repeat (L), a serine-threonine protein kinase catalytic domain (PK), an alpha-helical coiled-coil region (H), and a putative transmembrane-spanning tail (T). Multiple protein kinases that participate in cytoskeletal and cell cycle functions share homology with DMPK in the PK and H regions. DMPK plays a modulatory role in the control of intracellular Ca2+ concentration in muscle tissues.
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Alternative Name(s):
myotonic dystrophy protein kinase, DM, DM1, DMK, dystrophia myotonica 1 protein
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References:
- Zhang R, Epstein HF: Homodimerization through coiled-coil regions enhances activity of the myotonic dystrophy protein kinase. FEBS Lett. 546(2-3): 281-287 (2003).
- Meservy JL, Sargent RG, Iyer RR, Chan F, McKenzie GJ, Wells RD, Wilson JH: CTG tracts from the myotonic dystrophy gene induce deletions and rearrangements during recombination at the APRT locus in CHO cells. Mol. Cell. Biol. 23(9): 3152-3162 (2003).
- Furling D, Lam le T, Agbulut O, Butler-Browne GS, Morris GE: Changes in myotonic dystrophy protein kinase levels and muscle development in congenital myotonic dystrophy. Am. J. Pathol. 162(3): 1001-1009 (2003).
- Gennarelli M, Lucarelli M, Zelano G, Pizzuti A, Novelli G, Dallapiccola B: Different expression of the myotonin protein kinase gene in discrete areas of human brain. Biochem. Biophys. Res. Commun. 216(2): 489-494 (1995).
- Mahadevan MS, Amemiya C, Jansen G, Sabourin L, Baird S, Neville CE, Wormskamp N, Segers B, Batzer M, Lamerdin J, et al.: Structure and genomic sequence of the myotonic dystrophy (DM kinase) gene. Hum. Mol. Genet. 2(3): 299-304 (1993).PMID: 8499920 [PubMed - indexed for MEDLINE]
- Fu YH, Friedman DL, Richards S, Pearlman JA, Gibbs RA, Pizzuti A, Ashizawa T, Perryman MB, Scarlato G, Fenwick RG Jr, et al.: Decreased expression of myotonin-protein kinase messenger RNA and protein in adult form of myotonic dystrophy. Science 260(5105): 235-238 (1993).
- Fu YH, Pizzuti A, Fenwick RG Jr, King J, Rajnarayan S, Dunne PW, Dubel J, Nasser GA, Ashizawa T, de Jong P, et al.: An unstable triplet repeat in a gene related to myotonic muscular dystrophy. Science 255(5049): 1256-1258 (1992).
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For Research Use Only. Not for Diagnostic or Therapeutic Use.
Purchase does not include or carry any right to resell or transfer this product either as a stand-alone product or as a component of another product. Any use of this product other than the permitted use without the express written authorization of Orbigen, Inc. is strictly prohibited
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