Animal ID:
RC40104
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Host:
Chicken
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Reactivity:
human
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Buffers:
Purified chicken polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
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Storage:
Maintain refrigerated at 2-8ºC for up to 6 months. For long term storage store at -20ºC. Avoid repeated freeze-thaw cycles.
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Application:
Tested by peptide-specific ELISA (1:1,000).
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Immunogen:
Partial protein comprised of amino acids 388 - 541 of the human aryl hydrocarbon receptor (AHR) protein.
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Accession number:
NM_002376
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Description:
MAP/microtubule affinity-regulating kinase 3 (MARK3) is a member of the serine / threonine protein kinase family. Loss-of-function mutations in the MARK3 gene cause Peutz-Jeghers syndrome, which is associated with inherited susceptibility to colorectal and other cancers. No downstream targets of MARK3 kinase activity have been identified. MARK3 can direct the phosphorylation of the serine-threonine kinase PAR1A.
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Alternative Name(s):
KP78, CTAK1, PAR1A
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References:
- Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT: PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling. Nat. Cell. Biol. 3(7): 628-636 (2001).
- Peng CY, Graves PR, Ogg S, Thoma RS, Byrnes MJ 3rd, Wu Z, Stephenson MT, Piwnica-Worms H: C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding.Cell. Growth Differ. 9(3): 197-208 (1998).
- Ono T, Kawabe T, Sonta S, Okamoto T: Assignment of MARK3 alias KP78 to human chromosome band 14q32.3 by in situ hybridization. Cytogenet. Cell Genet. 79(1-2): 101-102 (1997).
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For Research Use Only. Not for Diagnostic or Therapeutic Use.
Purchase does not include or carry any right to resell or transfer this product either as a stand-alone product or as a component of another product. Any use of this product other than the permitted use without the express written authorization of Orbigen, Inc. is strictly prohibited
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