Animal ID:
RB0305-0306
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Host:
Rabbit
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Reactivity:
human
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Buffers:
Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
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Storage:
Maintain refrigerated at 2-8ºC for up to 6 months. For long term storage store at -20ºC. Avoid repeated freeze-thaw cycles.
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Application:
Tested by peptide-specific ELISA (1:1,000).
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Immunogen:
KLH conjugated synthetic peptide comprised of amino acids 438 - 454 [DGQLQVKVYWKKTEDPT] of the human Kallmann syndrome 1 (KAL1) protein.
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Accession number:
NM_000216
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Description:
The Kallmann syndrome 1 (KAL1) protein, also called anosmin, plays a key role in neural cell adhesion and axonal migration of GnRH neurons and olfactory nerves to the hypothalamus. The X-linked Kallmann syndrome which is caused by mutations in KAL1, consists of congenital, isolated, idiopathic hypogonadotropic hypogonadism and anosmia.
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Alternative Name(s):
HHA, KAL, KMS, ADMLX, KALIG-1, Kallmann syndrome-1 sequence, anosmin-1
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References:
- Soussi-Yanicostas N, Hardelin JP, Arroyo-Jimenez MM, Ardouin O, Legouis R, Levilliers J, Traincard F, Betton JM, Cabanie L, Petit C: Initial characterization of anosmin-1, a putative extracellular matrix protein synthesized by definite neuronal cell populations in the central nervous system. J. Cell. Sci. 109 ( Pt 7): 1749-1757 (1996).
- Hardelin JP, Levilliers J, Blanchard S, Carel JC, Leutenegger M, Pinard-Bertelletto JP, Bouloux P, Petit C: Heterogeneity in the mutations responsible for X chromosome-linked Kallmann syndrome. Hum. Mol. Genet. 2(4): 373-377 (1993).
- Franco B, Guioli S, Pragliola A, Incerti B, Bardoni B, Tonlorenzi R, Carrozzo R, Maestrini E, Pieretti M, Taillon-Miller P, et al.: A gene deleted in Kallmann's syndrome shares homology with neural cell adhesion and axonal path-finding molecules. Nature 353(6344): 529-536 (1991).
- Legouis R, Hardelin JP, Levilliers J, Claverie JM, Compain S, Wunderle V, Millasseau P, Le Paslier D, Cohen D, Caterina D, et al.: The candidate gene for the X-linked Kallmann syndrome encodes a protein related to adhesion molecules. Cell 67(2): 423-435 (1991).
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For Research Use Only. Not for Diagnostic or Therapeutic Use.
Purchase does not include or carry any right to resell or transfer this product either as a stand-alone product or as a component of another product. Any use of this product other than the permitted use without the express written authorization of Orbigen, Inc. is strictly prohibited
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