Animal ID:
RB1977/1978
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Host:
Rabbit
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Reactivity:
Human
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Buffers:
Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
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Storage:
Maintain refrigerated at 2-8ºC for up to 6 months. For long term storage store at -20ºC. Avoid repeated freeze-thaw cycles.
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Application:
Tested by peptide-specific ELISA (1:1,000).
WB (1:100 ~1:500)
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Immunogen:
KLH conjugated synthetic peptide comprised of amino acids 315 - 330 [SLIDTLKQKRPVTEMC] of the human amyloid beta (A4) protein-binding family B member 2 (APBB2) protein.
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Accession number:
NM_173075
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Description:
Amyloid beta (A4) protein-binding family B member 2 (APBB2) interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. APBB2 interacts with the beta-amyloid precursor protein and with APLP2 probably through two phosphotyrosine binding (PTB) domains.
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Alternative Name(s):
amyloid beta (A4) protein-binding family B member 2, FE65L, FE65L1, MGC35575, Fe65-like
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References:
- Blanco G, Irving NG, Brown SD, Miller CC, McLoughlin DM: Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor protein. Mamm. Genome. 9(6): 473-475 (1998).
- McLoughlin DM, Miller CC: The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system. FEBS Lett. 397(2-3): 197-200 (1996).
- Guenette SY, Chen J, Jondro PD, Tanzi RE: Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein. Proc. Natl. Acad. Sci. U S A. 93(20): 10832-10837 (1996).
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For Research Use Only. Not for Diagnostic or Therapeutic Use.
Purchase does not include or carry any right to resell or transfer this product either as a stand-alone product or as a component of another product. Any use of this product other than the permitted use without the express written authorization of Orbigen, Inc. is strictly prohibited
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