Animal ID:
RB1859-1860
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Host:
Rabbit
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Reactivity:
Human
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Buffers:
Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
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Storage:
Maintain refrigerated at 2-8ºC for up to 6 months. For long term storage store at -20ºC. Avoid repeated freeze-thaw cycles.
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Application:
Tested by peptide-specific ELISA (1:1,000).
WB (1:100 ~1:500), IHC (1:50 ~1:100)
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Immunogen:
KLH conjugated synthetic peptide comprised of amino acids 31 - 46 [DNHVHSSFIYRRLRNH] of the human bone morphogenetic protein 5 (BMP5) protein.
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Accession number:
NM_021073
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Description:
Bone morphogenetic proteins (BMPs) were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. All BMPs except BMP1 are members of the transforming growth factor-beta superfamily of secreted growth and differentiation factors and they signal through bone morphogenetic protein receptors (BMPRs), membrane-bound serine/threonine kinases. BMP proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. Bone morphogenetic protein 5 (BMP5) is an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. Additionally, BMP5 is differentially regulated during the formation of various tumors.
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Alternative Name(s):
bone morphogenetic protein 5, MGC34244, Bmp5
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References:
- Wordinger RJ, Agarwal R, Talati M, Fuller J, Lambert W, Clark AF: Expression of bone morphogenetic proteins (BMP), BMP receptors, and BMP associated proteins in human trabecular meshwork and optic nerve head cells and tissues. Mol. Vis. 8: 241-250 (2002).
- Luo J, Dunn T, Ewing C, Sauvageot J, Chen Y, Trent J, Isaacs W: Gene expression signature of benign prostatic hyperplasia revealed by cDNA microarray analysis. Prostate 51(3): 189-200 (2002).
- Cohen A, Mulas R, Seri M, Gaiero A, Fichera G, Marini M, Baffico M, Camera G: Meier-Gorlin syndrome (ear-patella-short stature syndrome) in an Italian patient: clinical evaluation and analysis of possible candidate genes. Am. J. Med. Genet. 107(1): 48-51 (2002).
- Jin Y, Lu HB, Liong E, Lau TY, Tipoe GL: Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors. Histol. Histopathol. 16(4): 1013-1019 (2001).
- Sakaue M, Kitazawa S, Nishida K, Kitazawa R, Maeda S: Molecular cloning and characterization of human bone morphogenic protein (BMP)-5 gene promoter. Biochem. Biophys. Res. Commun. 221(3): 768-772 (1996).
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For Research Use Only. Not for Diagnostic or Therapeutic Use.
Purchase does not include or carry any right to resell or transfer this product either as a stand-alone product or as a component of another product. Any use of this product other than the permitted use without the express written authorization of Orbigen, Inc. is strictly prohibited
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