Animal ID:
RC40104
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Host:
Chicken
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Reactivity:
N/A
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Buffers:
Purified chicken polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
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Storage:
Maintain refrigerated at 2-8ºC for up to 6 months. For long term storage store at -20ºC. Avoid repeated freeze-thaw cycles.
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Application:
Tested by peptide-specific ELISA (1:1,000).
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Immunogen:
C-terminal partial protein
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Accession number:
NM_138964
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Description:
Prokineticin 1 (EG-VEGF) and prokineticin 2 are mammalian homologues of mamba MIT1 and frog Bv8. Prokineticins exert their physiological roles through integral membrane protein receptors which contains seven putative transmembrane domains (G protein receptor, GPR). GPR proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response. Two endogenous prokineticin receptors, designated G protein-coupled receptor 73 (GPR73, PK-R1) and PK-R2 have been identified.
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Alternative Name(s):
Prokineticin receptor 1, , G protein-coupled receptor ZAQ
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References:
- :Soga T, Matsumoto S, Oda T, Saito T, Hiyama H, Takasaki J, Kamohara M, Ohishi T, Matsushime H, Furuichi K: Molecular cloning and characterization of prokineticin receptors. Biochim. Biophys. Acta 1579(2-3): 173-179 (2002).
- Masuda Y, Takatsu Y, Terao Y, Kumano S, Ishibashi Y, Suenaga M, Abe M, Fukusumi S, Watanabe T, Shintani Y, Yamada T, Hinuma S, Inatomi N, Ohtaki T, Onda H, Fujino M: Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors. Biochem. Biophys. Res. Commun. 293(1): 396-402 (2002).
- Lin DC, Bullock CM, Ehlert FJ, Chen JL, Tian H, Zhou QY: Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor. J. Biol. Chem. 277(22): 19276-19280 (2002).
- Parker R, Liu M, Eyre HJ, Copeland NG, Gilbert DJ, Crawford J, Sutherland GR, Jenkins NA, Herzog H: Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic organisation and assignment to human chromosome 11q21.1 and 2p14 and mouse chromosome 9 and 6. Biochim. Biophys. Acta 1491(1-3): 369-375 (2000).
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For Research Use Only. Not for Diagnostic or Therapeutic Use.
Purchase does not include or carry any right to resell or transfer this product either as a stand-alone product or as a component of another product. Any use of this product other than the permitted use without the express written authorization of Orbigen, Inc. is strictly prohibited
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