Animal ID:
RB0007-0008
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Host:
Rabbit
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Reactivity:
Primates
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Buffers:
Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
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Storage:
Maintain refrigerated at 2-8ºC for up to 6 months. For long term storage store at -20ºC. Avoid repeated freeze-thaw cycles.
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Application:
Tested by peptide-specific ELISA (1:1,000).
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Immunogen:
KLH conjugated synthetic peptide comprised of amino acids 45 - 62 [KSDYISLLASGTYLATAY] of the human CD151 antigen (CD151) protein.
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Accession number:
NM_004357
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Description:
CD151 antigen is a member of the transmembrane 4 superfamily, also known as tetraspanins. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. These proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD151 is known to complex with integrins and other tetraspanins. Additionally, CD151 is involved in cellular processes such as cell adhesion and may regulate integrin trafficking and/or function. It also enhances cell motility, invasion and metastasis of cancer cells.
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Alternative Name(s):
GP27, SFA1, PETA-3
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References:
- Ashman LK: CD151. J. Biol. Regul. Homeost. Agents. 16(3): 223-226 (2002). Review.
- Sincock PM, Fitter S, Parton RG, Berndt MC, Gamble JR, Ashman LK: PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function. J. Cell. Sci. 112 ( Pt 6): 833-844 (1999).
- Fitter S, Seldin MF, Ashman LK: Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms. Biochim. Biophys. Acta. 1398(1): 75-85 (1998).
- Fitter S, Tetaz TJ, Berndt MC, Ashman LK: Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3. Blood 86(4): 1348-1355 (1995).
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For Research Use Only. Not for Diagnostic or Therapeutic Use.
Purchase does not include or carry any right to resell or transfer this product either as a stand-alone product or as a component of another product. Any use of this product other than the permitted use without the express written authorization of Orbigen, Inc. is strictly prohibited
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