Animal ID:
RB1913/1914
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Host:
Rabbit
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Reactivity:
Human
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Buffers:
Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
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Storage:
Maintain refrigerated at 2-8ºC for up to 6 months. For long term storage store at -20ºC. Avoid repeated freeze-thaw cycles.
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Application:
Tested by peptide-specific ELISA (1:1,000).
IHC (1:50 ~1:100)
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Immunogen:
KLH conjugated synthetic peptide comprised of amino acids 1224 - 1238 [RAVRSINEARYAGKE] of the human jagged 2 (JAG2) protein.
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Accession number:
NM_002226
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Description:
The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. Jagged-2 (JAG2) is a cell surface protein which is one of several ligands that activate Notch and related receptors. Jag2 plays an important role for male germ cells to differentiate or at least to survive in the rat testis and fails to express in the testis of spermatogenic maturation arrest patients.
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Alternative Name(s):
HJ2, JAG2
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References:
- Hayashi T, Kageyama Y, Ishizaka K, Xia G, Kihara K, Oshima H: Requirement of Notch 1 and its ligand jagged 2 expressions for spermatogenesis in rat and human testes. J. Androl. 22(6): 999-1011 (2001).
- Deng Y, Madan A, Banta AB, Friedman C, Trask BJ, Hood L, Li L: Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene. Genomics 63(1): 133-138 (2000).
- Lanford PJ, Lan Y, Jiang R, Lindsell C, Weinmaster G, Gridley T, Kelley MW: Notch signalling pathway mediates hair cell development in mammalian cochlea. Nat. Genet. 21(3): 289-292 (1999).
- Gray GE, Mann RS, Mitsiadis E, Henrique D, Carcangiu ML, Banks A, Leiman J, Ward D, Ish-Horowitz D, Artavanis-Tsakonas S: Human ligands of the Notch receptor. Am. J. Pathol. 154(3): 785-794 (1999).
- Luo B, Aster JC, Hasserjian RP, Kuo F, Sklar J: Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. Mol. Cell. Biol. 17(10): 6057-6067 (1997).
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For Research Use Only. Not for Diagnostic or Therapeutic Use.
Purchase does not include or carry any right to resell or transfer this product either as a stand-alone product or as a component of another product. Any use of this product other than the permitted use without the express written authorization of Orbigen, Inc. is strictly prohibited
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