Animal ID:
RC40104
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Host:
Chicken
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Reactivity:
human
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Buffers:
Purified chicken polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
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Storage:
Maintain refrigerated at 2-8ºC for up to 6 months. For long term storage store at -20ºC. Avoid repeated freeze-thaw cycles.
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Application:
Tested by peptide-specific ELISA (1:1,000).
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Immunogen:
Partial protein comprised of amino acids 1 - 92 of the human transient receptor potential cation channel (TRPV1) protein.
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Accession number:
NM_018727
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Description:
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. TRPV1 is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo.
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Alternative Name(s):
VR1, DKFZp434K0220, capsaicin receptor, vanilloid receptor subtype 1
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References:
- Renton T, Yiangou Y, Baecker PA, Ford AP, Anand P: Capsaicin receptor VR1 and ATP purinoceptor P2X3 in painful and nonpainful human tooth pulp. J. Orofac. Pain. 17(3): 245-250 (2003).
- Mohapatra DP, Nau C: Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway. J. Biol. Chem. 278(50): 50080-50090 (2003).
- Numazaki M, Tominaga T, Takeuchi K, Murayama N, Toyooka H, Tominaga M.: Structural determinant of TRPV1 desensitization interacts with calmodulin. Proc. Natl. Acad. Sci. U S A. 100(13): 8002-8006 (2003).
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For Research Use Only. Not for Diagnostic or Therapeutic Use.
Purchase does not include or carry any right to resell or transfer this product either as a stand-alone product or as a component of another product. Any use of this product other than the permitted use without the express written authorization of Orbigen, Inc. is strictly prohibited
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