Animal ID:
RB1795/1796
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Host:
Rabbit
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Reactivity:
human
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Buffers:
Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
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Storage:
Store at -20ºC. Avoid repeated freeze-thaw cycles.
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Application:
Tested by peptide-specific ELISA (1:1,000).
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Immunogen:
KLH conjugated synthetic peptide comprised of amino acids 323 - 337 [IRSGVQRSPPRRASS] of the human Baculoviral IAP repeat-containing 5 (BIRC5) protein.
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Accession number:
NM_001168
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Description:
Baculoviral IAP repeat-containing 5 (BIRC5) is a member of a family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. BIRC5 is an apoptosis inhibitor which is expressed during the G2/M phase of the cell cycle. BIRC5 associates with the microtubules of the mitotic spindle and any disruption results in the loss of apoptosis activity.
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Alternative Name(s):
EPR1, API4, survivin, API-4, apoptosis inhibitor 4
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References:
- Kim PJ, Plescia J, Clevers H, Fearon ER, Altieri DC: Survivin and molecular pathogenesis of colorectal cancer. Lancet 362(9379): 205-209 (2003).
- Zhu XD, Lin GJ, Qian LP, Chen ZQ: Expression of survivin in human gastric carcinoma and gastric carcinoma model of rats. World J. Gastroenterol. 9(7): 1435-1438 (2003).
- Sommer KW, Schamberger CJ, Schmidt GE, Sasgary S, Cerni C: Inhibitor of apoptosis protein (IAP) survivin is upregulated by oncogenic c-H-Ras. Oncogene 22(27): 4266-4280 (2003).
- Lens SM, Wolthuis RM, Klompmaker R, Kauw J, Agami R, Brummelkamp T, Kops G, Medema RH: Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension. EMBO J. 22(12): 2934-2947 (2003).
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For Research Use Only. Not for Diagnostic or Therapeutic Use.
Purchase does not include or carry any right to resell or transfer this product either as a stand-alone product or as a component of another product. Any use of this product other than the permitted use without the express written authorization of Orbigen, Inc. is strictly prohibited
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